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This fragmentation hurts portability. Code that performs well on one runtime may behave differently (or poorly) on another, even though it's using "standard" APIs. The complexity burden on runtime implementers is substantial, and the subtle behavioral differences create friction for developers trying to write cross-runtime code, particularly those maintaining frameworks that must be able to run efficiently across many runtime environments.
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Fund yourself until you can’t. Pitch customers before investors. Chase traction before capital. Build something worth defending before handing over the keys.
A microfluidics chip enables researchers to manipulate and study individual cells, without the use of agar at all. Credit: Brouzes E. et al. PNAS (2009).